2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15340R
    LG100268 (Standard) 153559-76-3 98%
    LG100268 (Standard) is the analytical standard of LG100268. This product is intended for research and analytical applications. LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively. LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively. LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy.
    LG100268 (Standard)
  • HY-153527
    GalNac-L96 analog 1159408-72-6 98%
    GalNAc-L96 analog is an intermediate in the synthesis of the asialoglycoprotein receptor (ASGPR) ligand GalNAc-L96 (HY-147012).
    GalNac-L96 analog
  • HY-153812
    AST 7062601 675197-89-4 98%
    AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration.
    AST 7062601
  • HY-153826
    C8-Glucosylceramide 111956-47-9 98%
    C8-Glucosylceramide is a glycosphingolipid.
    C8-Glucosylceramide
  • HY-153827
    C12 Glucosyl(β) ceramide (d18:1/12:0) 111956-48-0 98%
    C12 Glucosyl(β) ceramide (d18:1/12:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
    C12 Glucosyl(β) ceramide (d18:1/12:0)
  • HY-153828
    LacCer (d18:1/8:0) 384842-72-2 98%
    LacCer (d18:1/8:0) is a glycosphingolipid.
    LacCer (d18:1/8:0)
  • HY-153861
    LacCer(d18:1/24:1) 483370-78-1 98%
    LacCer(d18:1/24:1) is a sphosphingolipid.
    LacCer(d18:1/24:1)
  • HY-153867
    C12 Mono-Sulfo galactosyl(β) ceramide (d18:1/12:0) ammonium 852043-39-1 98%
    C12 Mono-Sulfo galactosyl(β) ceramide (d18:1/12:0) ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
    C12 Mono-Sulfo galactosyl(β) ceramide (d18:1/12:0) ammonium
  • HY-153868
    C17-Mono-sulfo galactosyl(β) ceramide (d18:1/17:0) ammonium 1246303-23-0 98%
    C17-Mono-sulfo galactosyl(β) ceramide (d18:1/17:0) ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
    C17-Mono-sulfo galactosyl(β) ceramide (d18:1/17:0) ammonium
  • HY-153869
    18:0 (2R-OH) Sulfo GalCer ammonium 2260670-26-4 98%
    18:0 (2R-OH) Sulfo GalCer (ammonium) is a glycosphingolipid.
    18:0 (2R-OH) Sulfo GalCer ammonium
  • HY-153871
    C24:1 Mono-sulfo Galactosyl (β) ceramide (d18:1/24:1) ammonium 1246355-69-0 98%
    C24:1 Mono-sulfo Galactosyl (β) ceramide (d18:1/24:1) (ammonium) is a glycosphingolipid.
    C24:1 Mono-sulfo Galactosyl (β) ceramide (d18:1/24:1) ammonium
  • HY-153872
    C24 Mono-Sulfo Galactosyl(β) Ceramide (d18:1/24:0) ammonium 1246304-32-4 98%
    C24 Mono-Sulfo Galactosyl(β) Ceramide (d18:1/24:0) (ammonium) is a glycosphingolipid.
    C24 Mono-Sulfo Galactosyl(β) Ceramide (d18:1/24:0) ammonium
  • HY-153924
    Di-22:6-BMP 319003-15-1 98%
    Di-22:6-BMP is a bisphospholipid and also a structural isomer of phosphatidylglycerol. Di-22:6-BMP serves as a biomarker for drug-induced phospholipidosis in rats.
    Di-22:6-BMP
  • HY-15401A
    WAY 163909 (hydrochloride) 428868-35-3 98%
    WAY 163909 hydrochloride is an orally active, blood-brain barrier permeable 5-HT2C receptor-selective agonist. WAY 163909 hydrochloride exhibits an EC50 of 8 nM and a Ki of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 hydrochloride induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 hydrochloride alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 hydrochloride can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia.
    WAY 163909 (hydrochloride)
  • HY-15408R
    Trelagliptin (Standard) 865759-25-7 98%
    Trelagliptin (Standard) is the analytical standard of Trelagliptin. This product is intended for research and analytical applications. Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).
    Trelagliptin (Standard)
  • HY-15438R
    SB 415286 (Standard) 264218-23-7 98%
    SB 415286 (Standard) is the analytical standard of SB 415286. This product is intended for research and analytical applications. SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β.
    SB 415286 (Standard)
  • HY-15461S
    Ertugliflozin-d5 1298086-22-2 98%
    Ertugliflozin-d5 is the deuterium labeled Ertugliflozin. Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus.
    Ertugliflozin-d5
  • HY-154858
    C55 Prenol 50426-50-1 98%
    C55 Prenol is an ester product.
    C55 Prenol
  • HY-155165
    Dazonone 105622-85-3 98%
    Dazonone is a phosphodiesterase III inhibitor with the IC50 of 1.68 μM.
    Dazonone
  • HY-15516R
    Sotagliflozin (Standard) 1018899-04-1 98%
    Sotagliflozin (Standard) is the analytical standard of Sotagliflozin. This product is intended for research and analytical applications. Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.
    Sotagliflozin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity